Concentration-dependent systemic response after inhalation of nano-sized zinc oxide particles in human volunteers
نویسندگان
چکیده
منابع مشابه
Organ burden and pulmonary toxicity of nano-sized copper (II) oxide particles after short-term inhalation exposure
INTRODUCTION Increased use of nanomaterials has raised concerns about the potential for undesirable human health and environmental effects. Releases into the air may occur and, therefore, the inhalation route is of specific interest. Here we tested copper oxide nanoparticles (CuO NPs) after repeated inhalation as hazard data for this material and exposure route is currently lacking for risk ass...
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ZnO plays an important role in many semiconductors technological aspects. Here, direct precipitation method was employed for the synthesis of nano-sized hexagonal ZnO particles, which is based on chemical reactions between raw materials used in the experiment. ZnO nanoparticles were synthesized by calcinations of the ZnO precursor precipitates at 250 ˚C for 3hours. ...
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RATIONALE Zinc oxide is a common, biologically active constituent of particulate air pollution as well as a workplace toxin. Ultrafine particles (< 0.1 microm diameter) are believed to be more potent than an equal mass of inhaled accumulation mode particles (0.1-1.0 microm diameter). OBJECTIVES We compared exposure-response relationships for respiratory, hematologic, and cardiovascular endpoi...
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The increasing uses of zinc oxide nanoparticles (nZnO) in industrial and personal care products raise possible danger of using nZnO in human. To determine whether ZnO induces size-dependent anomalies during embryonic organogenesis, mouse embryos on embryonic day 8.5 were cultured for 2 days under 50, 100, and 150 μg of nZnO (< 100 nm) or micro-sized ZnO (mZnO; 80 ± 25 μm), after which the morph...
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Exposure to air polluted with particles less than 2.5 micron in size is associated epidemiologically with adverse cardiopulmonary health consequences in humans. The goal of this study was to characterize human pulmonary responses to controlled experimental high-dose exposure to fine and ultrafine magnesium oxide particles. We quantified bronchoalveolar lavage (BAL) cell and cytokine concentrati...
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ژورنال
عنوان ژورنال: Particle and Fibre Toxicology
سال: 2018
ISSN: 1743-8977
DOI: 10.1186/s12989-018-0246-4